This module explores the role of stem cells and epigenetics in the biology of aging. Learners will examine the defining features of stem cells, how somatic stem cell function declines with age, and examples of age-related stem cell dysfunction. The content also introduces cellular reprogramming, including partial reprogramming and direct reprogramming, and reviews their potential clinical applications as well as current challenges in the aging field. In addition, the modules explore epigenetic regulation, common assays used to study epigenetic changes, and how epigenetic alterations are linked to aging, stem cell function, and cancer. Together, these topics provide a foundation for understanding how regenerative biology and epigenetics contribute to aging research and the development of future therapies.

Lecture 1: Stem Cells

By the end of this lecture, learners will be able to:

• Define stem cells

• Understand the features of somatic stem cells

• Give examples of impaired stem cell function with age

• Describe interventions that improve stem cell function

Lecture 2: Reprogramming and Rejuvenation

By the end of this lecture, learners will be able to:

• Understand cellular reprogramming

• Define partial reprogramming

• Understand the clinical potential of partial reprogramming and its challenges

• Describe direct reprogramming and its uses in the aging field

Lecture 3: Epigenetic Association with Cancer

By the end of this lecture, learners will be able to:

• Define epigenetic regulation and assays used to study them

• Convey connections between epigenetics and aging

• Describe reported alterations associated with aging in adult stem cells

• Summarize epigenetic association with cancer