This issue of What’s Hot addresses the importance of mobility as a fundamental component of health and well-being and details the impact of osteoarthritis on mobility for older adults in the United States. The publication covers up-to-date strategies to improve mobility — both nonpharmacologic approaches such as weight loss and physical activity and pharmacological approaches such as acetaminophen, glucosamine and chondroitin, topical or oral NSAIDS, and intraarticular injections. This useful reference details recommendations from guidelines that focus on prevention of disability as a main factor in maintenance of mobility and highlights the importance of a team in care of older adults with osteoarthritis. Support provided by Sanofi.